Влияние хлорорганических пестицидов на развитие острой кишечной инфекции неустановленной этиологии у детей, находящихся на грудном вскармливании, в условиях юга Кыргызстана

Rakhmanbek M. Toichuev; Liudmila V.  Zhilova; Kylych M.  Mamasharipov; Saparbai T. Zholdoshev; Asel U.  Toichueva; Kursanbek T.  Turdubaev; Akmaral T.  Argynbaeva; Abdymomun N.  Nasirov; Timur R.  Timur R. Paizildaev

doi:10.25514/CHS.2025.2.29007

Rakhmanbek M. Toichuev Institute of Medical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, Osh, Kyrgyzstan https://orcid.org/0000-0002-5978-6058
Liudmila V. Zhilova Research Institute of Biomedical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, Osh, Kyrgyzstan https://orcid.org/0000-0002-4530-6789
Kylych M. Mamasharipov Medical Faculty of the Osh State University, Osh, Kyrgyzstan https://orcid.org/0009-0002-6853-0668
Saparbai T. Zholdoshev Medical Faculty of the Osh State University, Osh, Kyrgyzstan https://orcid.org/0000-0003-3922-6659
Asel U. Toichueva Research Institute of Biomedical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, Osh, Kyrgyzstan https://orcid.org/0000-0001-6080-6469
Kursanbek T. Turdubaev Medical Faculty of the Osh State University, Osh, Kyrgyzstan https://orcid.org/0000-0003-3835-2282
Akmaral T. Argynbaeva Medical Faculty of the Osh State University, Osh, Kyrgyzstan https://orcid.org/0000-0003-3835-2282
Abdymomun N. Nasirov Research Institute of Biomedical Problems, South Branch of the National Academy of Sciences of the Kyrgyz Republic, Osh, Kyrgyzstan https://orcid.org/0009-0003-0085-4460
Timur R. Timur R. Paizildaev Medical Faculty of the Osh State University, Osh, Kyrgyzstan https://orcid.org/0000-0001-8909-1655

DOI: https://doi.org/10.25514/CHS.2025.2.29007

Keywords: children, breast milk, organochlorine pesticides, enteric infection, unknown etiology

Abstract

The article presents the results of studies of breast milk (BM) for organochlorine pesticides. BM samples were collected from the mothers of 37 sick breastfed newborns under 5 months of age. They received medical care at different medical facilities: hospitals, infectious disease departments, and private clinics for acute enteric infection (AEI), including neonatal pathologies and AEI with an unspecified pathogen. A series of tests were conducted for intestinal infections, enteroviruses, intrauterine infections, and other infections. OCP levels were detected in the BM of 36 (97.34%) nursing mothers of the examined children. No OCPs were detected in the BM of one mother, but her child was subsequently diagnosed with enzymopathy. Therefore, it is necessary to test the BM of the mothers for OCPs whose breastfed newborns were diagnosed with AEI with unknown source of infection.

References

Kramarev, S. A., Yankovsky, D. S., & Dyment, G. S. (2003). Efficacy of the multiprobiotic “Simbiter” and the fermented milk product “Simbivit” in intestinal infections in children. Women's Health, 3(15), 129‒132 (in Russ.).

Usenko, D. V. & Gorelova, E. A. (2017). Acute Intestinal Infections of Viral Etiology in Children: Prospect for Diagnosis and Therapy. Medical Council, (9), 86‒92 https://doi.org/10.21518/2079-701X-2017-9-86-92. (in Russ.).

Vasiliev, B. Ya., Vasilyeva, R. I., & Lobzin, Yu. V. (2000). Acute enteric diseases: rotaviruses and rotavirus infection. St. Petersburg: Lan, 272 p. ISBN: 5-8114-0253-8 (in Russ.).

Degtyarev, D. N., Astafieva, R. F., Ziyatdinov, M. N., Sibiryakova, G. N., & Donnikov A. E. (2017). Epidemiological aspects of rotavirus infection in maternity hospitals. Neonatology: News. Opinions. Training, (4 (18)), 161-167.Ardern-Holmes S.L. et al. (1999). Pediatric Infect. Dis. J. 18(7), 614–619 (in Russ.).

Ardern-Holmes, S. L., Lennon, D., Pinnock, R., Nicholson, R., Graham, D., Teele, D., ... & Stewart, J. (1999). Trends in hospitalization and mortality from rotavirus disease in New Zealand infants. The Pediatric infectious disease journal, 18(7), 614–619.

Dennehy P. H. (200). Pediatric Infect. Dis. J. 19 (Suppl. 10), 103–105.

Parashar U. D., Bresee J. S., Gentsh J. R., & Glass R. I. (1998). Emerging Infect. Dis. 4(4), 561. https://doi.org/10.3201/eid0404.980406.

Klyuchareva, A. A., Raevnev, A. E., Malyavko, D. V., & Pan'ko, O. A. (2002). Rotavirus infection in children. Medical news (in Russ.).

Bodnev, S. A., Maleev, V. V., Zhirakovskaya, E. V., Nikiforova, N. A., Korsakova, T. G., Tikunov, A. Yu., ... & Tikunova, N. V. (2008). Etiological significance of rotaviruses, noroviruses, and astroviruses in the structure of acute intestinal infections in young children of Novosibirsk during the seasonal increase in morbidity. Infectious diseases, 6(1), 61–64 (in Russ.).

Vorotyntseva, L. N. (2001). Acute intestinal infections in children. M.:Medicine (in Russ.).

Bondarenko, V. M., & Petrovskaya, V. G., Potaturkina-Nesterova, N. I. (1996). The problem of Klebsiella pathogenicity. Ulyanovsk: UlSU (in Russ.).

Ministry of Health of the Kyrgyz Republic. Department of Disease Prevention and State Sanitary and Epidemiological Surveillance https://dgsen.kg/deyatelnost/upravlenie-profilaktiki-infekcionnY/ostrye-kishechnye-infekcii-oki.html. (in Russ.).

Krasnogolovets, V. N., & Kiseleva, B. S. (1996). Klebsiella infections. M.:Medicine (in Russ.).

Toichuev, R. M., Shainazarov, T. Sh., Zholdoshev, S. T., & Nasirov, A. N. (2007). Peculiarities of the treatment of acute intestinal infection with an unspecified pathogen in the south of Kyrgyzstan. Proceedings of the VI Russian Congress “Modern Technologies in Pediatrics and Pediatric Surgery”. M.:Medicine P. 80. (in Russ.).

Toichuev, R. M., Zholdoshev, S. T., & Argynbaeva, A. T. (2006). Acute enteric infection (AEI) of unknown etiology in children in the Osh region. Proceedings of the V Russian Congress “Modern Technologies in Pediatrics and Pediatric Surgery”. M.: “OVERLAY”, 2006. P. 74. (in Russ.).

Turusbekova A. K. (2012). Social and Epidemiological Assessment of Infectious Pathology in Osh Oblast at the Current Stage. (Ph.D. dissertation) Bishkek: Osh State University.

Guidelines for the Bacteriological Testing of Breast Milk. Approved on April 28, 1984, by the USSR Ministry of Health. Moscow: USSR Ministry of Health. https://meganorm.ru/Data2/1/4293739/4293739022.pdf. (in Russ.).

Clinical and Bacteriological Diagnostics of Acute Enteric Infections. Methodological Guidelines for Microbiologists, Infectious Disease Specialists, and Epidemiologists. Kazan, 2003 (in Russ.).

Methodological recommendations. “Bacteriological diagnostics of intestinal dysbacteriosis”. Approved by the Ministry of Health of the RSFSR on April 14, 1977. M. (in Russ.). https://files.stroyinf.ru/Data2/1/4293755/4293755981.htm.

Bondarenko, V. M., & Likhoded, V. G. (2007). Microbiological Diagnostics of Intestinal Dysbacteriosis: Guidelines. Moscow: Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences. (in Russ.).

Guidelines for the Selective Gas Chromatographic Determination of Organochlorine Pesticides in Biological Environments (Urine, Blood, Adipose Tissue) and Breast Milk. No. 3151-84. Moscow: USSR Minzdrav. https://meganorm.ru/Data2/1/4293739/4293739022.pdf. (in Russ.).

Toichueva, A. U., Sakibaev, K. Sh., Paizildaev, T. R., Zhilova, L. V., & Toichuev, R. M. (2021). Breast milk as a biological marker for determining environmental pollution with organochlorine pesticides in southern Kyrgyzstan. Khimicheskaya Bezopasnost’ = Chemical Safety Science, 5(1), 215–236. https://doi.org/10.25514/CHS.2021.1.19014. (in Russ.).

Toichuev, R. M. (2016). Immunological aspects of the impact of organochlorine pesticides during pesticide penetration into the body through the gastrointestinal tract. European Journal of Natural History, (5), 28–32.

The Effect of Organochlorine Pesticides on the Development of Acute Enteric Infection of Unknown Etiology in Breastfed Children in Southern Kyrgyzstan

Abstract

References

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