Toxicological evaluation with determination of hazard classes of laureth-4-phosphate-based adjuvant using experimental and computational methods
Abstract
A preparation based on ethoxylated alcohol, widely used in agricultural production as an adjuvant (surfactant) together with pesticides of chemical synthesis, was chosen as an object of study of toxicity parameters. The paper presents original data of toxicological studies, carried out by experimental and calculated method, to determine the hazardous properties of adjuvant based on laureth-4-phosphate, used in the agricultural sector of the country together with pesticides of chemical synthesis. Also the paper reflects information on the classification of hazards of the studied chemical products for human health, obtained as a result of application of two different methods - calculated and experimental, for assessment by parameters of acute intragastric toxicity and acute toxicity when applied to the skin, assessment by parameters of allergy hazard.
One of the main criteria in selecting an approach for toxicological studies of chemical products is the completeness of available data on the hazardous properties of its components (toxicological profile). the use of a combined approach in complex toxicological studies of chemical products (using experimental and computational methods of establishing hazard classes) not only allows to obtain the most complete and comprehensive assessment of preparations in terms of hazardous properties for human health, but also provides a harmonious and comprehensive assessment of their properties.
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Copyright (c) 2025 Svetlana Yu. Petrova, Svetlana M. Kamliuk, and Tatyana N. Gomolko
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