Chemical-toxicological characteristics of organophosphorus compounds

Keywords: organophosphorus compounds, toxicology, destruction, intoxication

Abstract

Abstract – This article provides an overview of organophosphorus compounds (OPs), which have found completely different uses in different historical periods: from drugs, fire retardants and catalysts to pesticides. Separately, the mechanisms of their toxic effects on the human body are noted, and effective sets of measures used in medical practice to provide assistance to citizens whose bodies are exposed to OPs are described.

References

Watson, J. D., & Crick, F. H. (1953). Molecular structure of nucleic acids: A structure for deoxyribose nucleic acid. Nature, 171(4356), 737‒738. https://doi.org/10.1038/171737a0

Михайлович В.А. (1990). Руководство для врачей скорой помощи. 2-е изд., перераб. и доп. Л.: Медицина, С. 114‒116. ISBN 5-225-01503-4.

Michaelis, A., & Kaehne, R. (1898). Ueber das Verhalten Der Jodalkyle gegen die sogen. Phosphorigsäureester Oder O‐phosphine. Berichte der deutschen chemischen Gesellschaft, 31(1), 1048‒1055. https://doi.org/10.1002/cber.189803101190

Arbuzov, A. E. (1906). On the structure of phosphonic acid and its derivates: Isometization and transition of bonds from trivalent to pentavalent phosphorus. J. Russ. Phys. Chem. Soc, 38, 687.

Arbuzov, A. E. (1906). Formation of monoalkylphosphonic esters from alkyl halides and trialkyl phosphites, via the intermediate phosphonium salt. Chem. Zentr. II. 1639.

Забродский П.Ф. (2016). Иммунотоксикология фосфорорганических соединений. Саратов: Саратовский источник. 289 с. ISBN 978-5-91879-561-3

Лошадкин Н.А., Курляндский Б.А., Беженарь Г.В., Дарьина Л.В. (2006). Военная токсикология. M: Медицина, ISBN 5-225-04827-7.

Петренко Э.П., Фукс А.С. (2007). Военная токсикология, радиобиология и медицинская защита. Учебное пособие. Саратов: Фолиант.

Ross, A.G., Bartley, P.B., Sleigh, A.C., Olds, G.R., Li, Y., Williams, G.M., McManus, D.P. (2002). Schistosomiasis. The New England Journal of Medicine. 346(16), 1212–1220. https://doi.org/10.1056/NEJMra012396

Diaz-Resendiz, K. J. G.; Toledo-Ibarra, G. A.; Giron-Perez, M. I. (2015) Modulation of immune response by organophosphorus pesticides: fishes as a potential model in immunotoxicology Journal of Immunology Research, 1‒11 https://doi.org/10.1155/2015/213836

Li, Q. (2007). New mechanism of organophosphorus pesticide induced immunotoxicity,” Journal of Nippon Medical School, 74(2), 92–105. https://doi.org/10.1272/jnms.74.92

Jokanovic´ M. (2001). Biotransformation of organophosphorus compounds. Toxicology, 166 139–160. https://doi.org/10.1016/S0300-483X(01)00463-2.

Fonnum, F., Sterri, S. H. (1981). Factors modifying the toxicity of organophosphorus compounds including soman and sarin. Fundam. Appl. Toxicol. 1, 143–147. https://doi.org/10.1016/S0272-0590(81)80050-4.

Chandra, R., Pandey, O. P., Sengupta, S. K. (2005). Organophosphorus Derivatives Containing Piperazine Dithiosemicarbazones as Chemotherapeutants against Fungal Pathogens of Sugarcane. Journal of Agricultural and Food Chemistry. 53(6), 2181-2184. https://doi.org/10.1021/jf040134m

Published
2023-06-05
How to Cite
Shiryaev, S. D., & Lobanov, A. V. (2023). Chemical-toxicological characteristics of organophosphorus compounds. Chemical Safety Science, 7(1), 48 - 58. https://doi.org/10.25514/CHS.2023.1.24004
Section
Chemical hazard sources. Hazardous chemical substances