The use of distillery grains as a pharmaceutical raw material for the production of betaines hydrochlorides

Abstract

Post-alcohol grains, in terms of production volume 12 times greater than the volume of alcohol production, containing biologically active substances, labile under environmental conditions, practically not utilized, available for processing, attracted attention from the point of view of its use as a pharmaceutical raw material. Technological, chemical, physicochemical and biological methods were used in the work. A method for producing drugs was developed: substances and tablets based on betaine hydrochlorides with the addition of pepsin, which have a digestive and enzymatic effect. For the first time, post-alcohol corn grains, richer in amino acids, larger-scale and more accessible than the traditional raw material, molasses, was used as a pharmaceutical raw material. The following betaines hydrochlorides were obtained by semi-synthesis from the amino acids contained in vinasse: glycine, glutamic acid, arginine, alanine, aspartic acid, tyrosine, histidine, serine, valine, leucine, lysine, threonine), the yield of which was 5.70% to the liquid phase, in the difference from the known drug "Acidin-pepsin", containing one betaine hydrochloride, isolated from molasses with a yield of 1.70%. It has been shown that an increase in the yield of betaines hydrochlorides is the result of an almost complete acidic hydrolysis of proteins and peptides; the release of not only betaines, but also the semisynthesis of betaines from amino acids, as well as special temperature conditions and the removal of accompanying carbohydrates. The resulting betaines of hydrochlorides have a high purity of 99.5–99.8%. The pharmaceutical and technological properties of granules and tablets have been optimized by correcting the technology for producing tablets and the composition of excipients, which resulted in an increase in the shelf life of the tablets. The tablets based on betaines hydrochlorides made from a new type of raw material and using a modified technology are practically non-toxic and, in terms of their hyperacid and proteolytic action, are not inferior to their foreign counterparts - tablets “Acidin-pepsin”.