Organochlorine pesticides in breast milk of urban women residents of Kyrgyzstan
Abstract
The article presents the results of analysis for organochlorine pesticides (OCPs) present in breast milk of urban women residents of Kyrgyzstan aged 18 to 35 years who gave birth to sick and healthy children, aged 7–28 days at the time of examination. The first test group included 57 mothers of newborn children with various types of pathologies, and the second test group involved 84 mothers of healthy newborns. The beast milk was examined for the presence of 10 kinds of OCPs: hexachlorocyclohexane (HCH) in the form of its α-, β-, γ-, and δ-isomers; 4,4'-dichlorodiphenyltrichloroethane (4,4'-DDT), 4,4'-dichlorodiphenyldichlorethylene (4,4′-DDE), 4,4′-dichlorodiphenyldichloroethane (4,4′-DDD), aldrin, dildrin, and heptachlor, eventually, eight of them were detected, excluding δ-HCH and dildrin. In total, 69 of 141 (49%) women were found to have OCPs revealed in the breast milk samples, while the maximum detected concentrations were 0.07527 ± 0.0097 mg/L (γ-HCH) and 0.05089 ± 0.0067 mg/L (4,4′-DDE). In the group I, OCPs were detected in the breast milk of 89.47% of persons with the average amount of 2.6 species of OCPs per one sample, but in the group II, OCPs were also detected in 21.43% of individuals (4,4′-DDE and HCH), with the average amount of 1.2 species of OCPs per one sample. Apparently, a relationship is observed between the concentration and the number of OCP species in the breast milk and the health status of mothers and their newborn children in both groups. Some children which were born healthy had subsequently developed pathologies precisely in those cases when OCPs were present in the mother’s breast milk. Women with the presence of OCPs in the breast milk should be assigned to the risk group whith an urgent need for their preventive treatment before the development of pathology in children and mothers themselves occurs.
References
Fiedler, H., Kallenborn, R., de Boer, J., & Sydnes, L.K. (2019). The Stockholm convention: a tool for the global regulation of Persistent Organic Pollutants. Chemistry International, 41(2), 4 - 11. https://doi.org/10.1515/ci-2019-0202
Carpenter, D.O. (2013). Effects of Persistent and Bioactive Organic Pollutants on Human Health. John Wiley & Sons. DOI:10.1002/9781118679654
Upadhayay, J., Rana, M., Juyal, V., Bisht, S.S., & Joshi, R. (2020). Impact of pesticide exposure and associated health effects. In: Pesticides in crop production: physiological and biochemical action. Ed. Srivastava P.K. et al. Chapter 5, pp. 69 - 88. Wiley Online Library. https://doi.org/10.1002/9781119432241.ch5
Toichuev, R.M., Zhilova, L.V., Makambaeva, G.B., Payzildaev, T.R., Pronk, W., Bouwknegt, M., & Weber, R. (2018). Assessment and review of organochlorine pesticide pollution in Kyrgyzstan. Environmental Science and Pollution Research, 25(32), 31836 - 31847. https://doi.org/10.1007/s11356-017-0001-7
Toicuev, R.M., & Toichueva, A.U. (2019). Monitoring of organochlorine pesticides in breast milk of women of Kyrgyzstan. Khimicheskaya Bezopasnost’ = Chemical Safety Science, 3(2), 94 - 109 (in Russ.). https://doi.org/10.25514/CHS.2019.2.16004
Paizildaev, T. (2017). Contamination of breast milk with organochlorine pesticides in the Osh Province of the Kyrgyz Republic. Proceedings of 29th Annual Sci. Conf. International Society of Environmental Epidemiology (ISEE 2017). Sydney, Australia.
Toichuev, R.M., Zhilova, L.V., Payzildaev, T.R., Khametova, M.S., Rakhmatillaev, A., Sakibaev, K.S., Madykova, Z.A., Toichueva, A.U., Schlumpf, M., Weber, R., & Lichtensteiger, W. (2018). Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health. Environmental Science and Pollution Research, 25(32), 31885 - 31894. https://doi.org/10.1007/s11356-017-0962-6
Johnson-Restrepo, B., Addink, R., Wong, C., Arcaro, K., & Kannan, K. (2007). Polybrominated diphenyl ethers and organochlorine pesticides in human breast milk from Massachusetts, USA. J. Environ. Monit., 9(11), 1205 - 1212. https://doi.org/10.1039/B711409P
Croes, K., Colles, A., Koppen, G. , Govarts, E., Bruckers, L., Van de Mieroop, E., Nelen, V., Covaci, A., Dirtu, A.C., Thomsen, C., Haug, L.S., Becher, G., Mampaey, M., Schoeters, G., Van Larebeke, N., & Baeyens, W. (2012). Persistent organic pollutants (POPs) in human milk: a biomonitoring study in rural areas of Flanders (Belgium). Chemosphere, 89(8), 988 - 994. https://doi.org/10.1016/j.chemosphere.2012.06.058
Banyiova, K., Cerna, M., Mikes, O., Komprdova, K., Sharma, A., Gyalpo, T., Cupr, P., & Scheringer, M. (2017). Long-term time trends in human intake of POPs in the Czech Republic indicate a need for continuous monitoring. Environment International, 108, 1 - 10. https://doi.org/10.1016/j.envint.2017.07.008
Malevich, Yu.K., & Simonova, E.V. (2003). Organochlorine pesticides and their impact on quality composition of breast milk of puerperas. Belorusskii Meditsynskii Zhurnal = Белорусский медицинский журнал = Belarusian Medical Journal, 3, 86 - 88 (in Russ.). http://rep.bsmu.by/handle/BSMU/6299
Hedley, A.J., Hui, L.L., Kypke, K., Malisch, R., van Leeuwen, F.X.R., Moy, G., Wong, T.W., & Nelson, E.A.S. (2010). Residues of persistent organic pollutants (POPs) in human milk in Hong Kong. Chemosphere, 79(3), P. 259 - 265. DOI: https://doi.org/10.1016/j.chemosphere.2010.01.047
Toguzbaeva, K.K., Niyazbekova, L.S., Seiduanova, L.B., Toleu, E.T., Zhakanov, A.Zh., Elgondina, G.B., Aizharyk, A.V., & Kaldybai, D.N. (2016). Impact of environmental factor on health status of rural population. Mezhdunarodnyi zhurnal prikladnykh i fundamentalnykh issledovanii = International Journal of Applied and Basic Research, 4-2, 507 - 510 (in Russ.).
Hui, L.L., Hedley, A.J., Kypke, K., Cowling, B.J., Nelson, E.A.S., Wong, T.W., van Leuween, F.X.R., & Malisch, R. (2008). DDT levels in human milk in Hong Kong, 2001-02. Chemosphere, 73(1), 50 - 55. https://doi.org/10.1016/j.chemosphere.2008.05.045
Stuetz, W., Prapamontol, T., Erhardt, J.G., & Classen, H.G. (2001). Organochlorine pesticide residues in human milk of a Hmong hill tribe living in Northern Thailand. Sci. Total Environ., 273(1-3), 53 - 60. https://doi.org/10.1016/S0048-9697(00)00842-1
Wong, C.K.C., Leung, K.M., Poon, B.H.T., Lan, C.Y., & Wong, M.H. (2002). Organochlorine Hydrocarbons in Human Breast Milk Collected in Hong Kong and Guangzhou. Archives of Environmental Contamination and Toxicology, 43(3), 0364 - 0372. https://doi.org/10.1007/s00244-002-1210-7
Lee, S., Kim, S., Lee, H.K., Lee, I.-S., Park, J., Kim, H.-J., Lee, J.J., Choi, G., Kim, S., Kim, S.Y., Choi, K., Kim, S., & Moon, H.-B. (2013). Contamination of polychlorinated biphenyls and organochlorine pesticides in breast milk in Korea: Time-course variation, influencing factors, and exposure assessment. Chemosphere, 93(8), 1578 - 1585. https://doi.org/10.1016/j.chemosphere.2013.08.011
Mamontova, Ye.A., Tarasova, Ye.N., Kuzmin, M.I., Maklakhan, M.S., Papke, O., & Mamontov, A.A. (2010). The levels of stable organic pollutants in the breast milk of women living in the Irkutsk region. Gigiena i sanitariya = Hygiene and Sanitation, 1, 35 - 38 (in Russ.).
Sergeyev, O., Shelepchikov, A., Denisova, T., Revich, B., Saharov, I., Sotskov, Y., Brodsky, E., Teplova, S., Sarayeva, N., & Zeilert, V. (2008). POPs in human milk in Chapaevsk, Russia, five years following cessation of chemical manufacturing and decade of remediation program, pilot study. Organohalogen Compounds, 70, 001946 - 001947.
Tsygankov, V.Yu., Gumovskaya, Yu.P., Gumovskiy, A.N., Koval, I.P., & Boyarova, M.D. (2020). Organic chlorine compounds in breast milk of women in the south of the Russian Far East. Ekologiya cheloveka = Human Ecology, 4, 12 - 18 (in Russ.). DOI: 10.33396/1728-0869-2020-4-12-18
Cok, A., Bilgili, M., Ozdemir, H., Ozbek, H., Bilgili, N., & Burgaz, S. (1997). Organochlorine pesticide residues in human breast milk from agricultural regions of Turkey, 1995-1996. Bull. Environ. Contam. Toxicol., 59, 577 - 582. https://doi.org/10.1007/s001289900518
Tadevosyan, N.S. (2016). Monitoring of certain organochlorine pesticides in rural female population of Armenia and indices of physical development of newborns and infants. Vestnik KGMA I.K. Akhunbaeva = Bulletin of Kyrgyz State Medical Academy named after I.K. Akhunbaev, 5, 159 - 164 (in Russ.).
Toichuev, R.M. (2007). Biological media as an indicator of pesticide environmental pollution in southern Kyrgyzstan. Proceedings of 9th International HCH and Pesticides Forum for Central and Eastern European, Caucasus and Central Asia Countries. Abstracts/ September 20-22, 2007 Chisinau, Republic of Moldova. P. 67.
Toichuev, R.M. (2016). Immunological aspects of the impact of organochlorine pesticides during pesticide penetration into the body through the gastrointestinal tract. European Journal of Natural History, 5, 28 - 33.
Toichuev, R.M., Shainazarov, T.Sh., Nematov, M.A., Abduraimova, Ch.D., & Paizova, Z.M. (2004). Change in immunoglobulins content in breast milk of lactating mother, depending on concentration of organochlorine pesticides in breast milk. Proceedings of 3rd Russian Congress “Modern Technologies in Pediatrics and Pediatric Surgery”. M.: MEDPRAKTIKA. P. 396 - 397 (in Russ.).
Toichuev, R. (2011).Elimination of organochlorine pesticides from the body by using herbal medicines. ISEE, 2011, 13-16 September, Barcelona, Spain. No. 597.
Toichuev, R.M. (2007). Medical and environmental problems of the south of Kyrgyzstan. 3rd National Congress on Respiratory Diseases, April 19-21, 2007, Osh, Kyrgyzstan. Tsentralno-Aziatskii Meditsynskii zhurnal = Центрально-Азиатский медицинский журнал = Central Asian Medical Journal, 13, Suppl. 1, 22 - 25 (in Russ.).
Bacteriological control of breast milk. Methodological Recommendations. TsNIIE MZ, MNIIEiM, TsOLIUV, Research Institute of Pediatrics and Pediatric Surgery. М., 1984.
Guidelines for selective gas chromatographic determination of organochlorine pesticides in biological media (urine, blood, adipose tissue) and in breast milk. Procedural details No. 3151-84. М., 1990 (in Russ.).
Petreas, M., Hooper, K., She, J., Visita, P., Winkler, J., McKinney, M., Mok, M., Sy, F., Garcha, J., Gill, M., & Stephens R. (1996). Analysis of human breast milk to assess exposure to chlorinated contaminants in Kazakhstan. Organohalogen Compounds, 30, 20 - 23.
Subramanian, A., Ohtake, M., Kunisue, T., & Tanabe, S. (2007). High levels of organochlorines in mothers' milk from Chennai (Madras) city, India. Chemosphere, 68(5), 928 - 939. https://doi.org/10.1016/j.chemosphere.2007.01.041
Konoplev, A., Gavrilenko, O., & Kochetkov, A. (2006). Organohalogen Compounds, 68, 1611 - 1614.
Toichuev, R.M. (2013). Effect of contamination with organochlorine pesticides of breast milk of lactating mothers on intestinal biocenosis status of newborns. Proceedings of XIIIth International Congress of Pediatricians of the Turkic world and the countries of Eurasia “Actual problems of pediatrics and pediatric surgery”, city of Cholpon-Ata (Kyrgyzstan), June 26-28, 2013. Zdorovie materi i rebyonka = Maternal and Child Health, 5(2), 31 - 34 (in Russ.).
Toichuev, R.M., & Tostokov, E.T. (2006). The effect of organochlorine pesticides (OCPs) on the formation of congenital disorders in children. Proceedings of Vth Russian Congress “Modern technologies in pediatrics and pediatric surgery”. М.: Izd. Overlei. P. 308 (in Russ.).
Toichuev, R.M., & Tostokov, E.T. (2006). The effect of organochlorine pesticides (OCPs) on the formation of congenital tumors in children. Proceedings of Vth Russian Congress “Modern technologies in pediatrics and pediatric surgery”. М.: Izd. Overlei. P. 315 (in Russ.).
Toichuev, R.M., & Tostokov, E.T. (2006). The effect of organochlorine pesticides on intrauterine condition of newborns. Proceedings of Vth Russian Congress “Modern technologies in pediatrics and pediatric surgery”. М.: Izd. Overlei. P. 247 (in Russ.).
Toichuev, R.M. (2006). Peculiarities of the prevention of intrauterine infection of fetus and newborns in conditions with adverse environmental effects. Proceedings of Vth Russian Congress “Modern technologies in pediatrics and pediatric surgery”. М.: Izd. Overlei. P. 246 (in Russ.).
Copyright (c) 2020 Rakhman M. Toichuev , Lyudmila V. Zhilova, Asel U. Toichueva, Timur R. Paizildaev, Madina Sh. Khametova, and Abdygapar Rakhmatillaev
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