Modern analytical approaches for chemical safety control - a review
Abstract
One of the most important tasks for ensuring chemical safety is development of modern analytical procedures for relevant and time-bound detection and identification of toxicity of chemical compounds in different sources, with high accuracy and reliability. This review highlights current issues of sanitary-chemical expertise covering the necessity to expand the range of regulated compounds taking into account products of their chemical transformation which are often even more toxic than starting materials, as well as the need to take into consideration a complex effect of hazardous substances on living organisms and the environment. An integrated chemical and toxicological analytical approach is discussed which combines both targeted and non-targeted analyses with bioassay-directed procedures. Innovative approaches to examining hazardous chemical sources are considered, such as quantitative structure-activity relationship(s), prioritization of the most hazardous substances, including progress in developing methodology for detection and identification of organic compounds derived from variable sources. High expectations are associated with the improvement of in silico approaches for assessing toxicity. It is emphasized a key role of high-performance liquid chromatography-mass spectrometry in the detection, identification, multitargeted screening and quantification of toxic organic compounds. Possible ways for upgrading the concept of chemical safety control in the Russian Federation are proposed.
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