Scopus ID: 9735705000

Doctor habil. (Biology), Chief Researcher, Federal Research Center of Problem of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka, Russia

Highly qualified expert in the field of chemical kinetics, enzymology, chemical ecology, and environmental toxicology.

Scope of research interests: physical chemistry, biophysics, ecology. Research interests also include studies of kinetics and molecular mechanisms of reactions of physiologically active compounds with biological molecules - nucleotides, enzymes, biological macroergic compounds, etc.

In 2009, she defended her doctoral habil. dissertation entitled ‘Complex formation processes in the mechanism of action of ecotoxicants of anthropogenic origin’.

Key research results:

• A high ability of anthropogenic toxicants - pesticides for complex formation with metals and nucleotides has been shown;
• Patterns of transfer pesticide-metal complexes through cell liposomal membrane has been established;
• Inhibition of oxidizing enzymes (in particular, NADH oxidoreductases) by pesticides and their complexes with metals has been proven;
• Patterns for degradation of pesticides and their complexes with metals have been investigated and degradation products have been identified;
• The ability of pesticides to form complexes with DNA has been proved to be responsible for their genotoxicity and mutagenicity;
• A correlation has been established between toxic properties of pollutants and their rates of complex formation with adenosine triphosphoric acid (ATP);
• In 2010, i.e. 24 years after the Chernobyl nuclear power plant accident, monitoring the environmental status of cultivated lands and water bodies of 9 districts of the Oryol region was performed. Radiation doses were found to decrease up to acceptable levels. A trend of an increase in genotoxicity with an increase in levels of pesticides and other anthropogenic pollutants was revealed in the samples;
• Currently, studies are being conducted aiming at studying influence of physiologically active chemical compounds, i.e. potential drugs, upon energy metabolism and glycolysis of cancer cells. The ability of iron / NO-donor complexes to bind biological macroergic compounds (ATP, FEP, etc.) has been shown, the products and kinetic laws of the reactions have been established.

Author of more than 150 research publications in scientific research periodicals, inter alia chapters in 2 books.